Antonio Conte will not be looking forward to this one having suffered a shock defeat at Crystal Palace and with Watford boosted by victory over Arsenal. The major plus is the return of Alvaro Morata, who is at 9/4 as first goalscorer. It was Eden Hazard who starred in midweek against Roma and the Belgian is at 5/4 to score anytime. Marco Silva has taught us never to write his sides off, but Chelsea rarely lose in consecutive weeks.
The Foxes begin life without Craig Shakespeare just four months after making his appointment permanent. They lacked inspiration against West Brom and Swansea will be looking to capitalise. The hosts are at 9/5 to win, which seems a good shout with Leicester yet to identify any replacements for their former manager.
The season really starts here for Crystal Palace. They earned their first points of the season off Chelsea, of all teams, with Wilfried Zaha giving another reminder of how crucial he is to their survival hopes. Newcastle are rightly favourites at 19/20 as they've only lost once in the league at home, and that came on the opening day.
The Baggies have only lost once to a side outside the top six this season, but the Saints remain the favourites at 4/5. Even if Southampton finally found their scoring boots against Newcastle, their attack remains a problem and as Tony Pulis' set-up is likely to be cautious, we're backing under 2.5 goals and a draw at 5/2.
Jose Mourinho has endured a week of criticism for his tactics against Liverpool. Here, Manchester United are set to come out firing on all cylinders again. United have won by three or more goals on seven occasions this season and they're at 5/2 to do so again - even if Huddersfield have given a good account of themselves thus far, they crumbled the last time they faced top opposition in Spurs.
It's difficult to see anyone stopping Manchester City on current form. Pep Guardiola's men put seven past Stoke and saw off Napoli in the Champions League. Burnley have fared well against the big boys this season, beating Chelsea and drawing with Spurs and Liverpool, but it's been raining goals at the Etihad. Gabriel Jesus and Sergio Aguero are both at 9/4, though the former is the slightly more tempting pick because he has two in as many games. It could be a long afternoon for the Clarets.
Two sides in trouble meet at the bet365 stadium. Stoke have had the better of their four meetings in the top flight, winning two, drawing one, and losing just one. The Cherries' major problem is that they aren't scoring goals, with just four to show from their eight games. Stoke haven't exactly been inspiring themselves, but they look the safer option at 11/10.
In a business where only the best survive, Josh has made his living for many years by betting on the Football matches where he can find an edge.
Our Football membership gives you the chance to piggy back the work of a professional. Get the same betting opportunities that Josh uses for his own betting - a clear betting strategy to take you on the path to football profits.