Tottenham vs Chelsea
Spurs are rarely favourites against the Blues, but this game is an exception with Mauricio Pochettino's side at 21/20. A draw and a Chelsea win are both at 5/2.
Eden Hazard has returned to training this week and should be able to play some part in proceedings at Wembley. However, elsewhere Antonio Conte has big problems. Not only is his squad looking worryingly thin, he is now without the suspended Gary Cahill and Cesc Fabregas, both of whom were sent off in the shock 3-2 defeat to Burnley.
The visitors' best hope comes in the form of Alvaro Morata, who's at 2/1 to score in 90 minutes. The Spaniard contributed a goal and an assist when he came on last week. Harry Kane is perhaps the most obvious choice, yet the Tottenham striker traditionally starts the season slowly and has never scored a Premier League goal in August.
Spurs managed to overcome Chelsea 2-0 at home last season and that was when the Blues were at their best. Antonio Conte will be under enormous pressure if his men don't get something here.
Huddersfield vs Newcastle
David Wagner could not have asked for a better start to life in the top flight. As for Newcastle, the problems are already mounting, with Jonjo Shelvey suspended for his stamp on Dele Alli.
The Magpies should not be written off, though, despite them being the outsiders at 2/1. Huddersfield will expect things to get a lot tougher after their easy win against Crystal Palace.
When the sides faced each other in the Championship last season, they won one game apiece.