Borussia Dortmund vs Real Madrid
Undoubtedly the glamour tie of the evening, two of Group H's giants go head to head at the Signal Iduna Park. Real have endured a tricky start to La Liga and they lie fifth, so this may be a good time to play them for Peter Bosz's side. Equally, Madrid will want to take advantage of Dortmund's injury problems. One man who will be looking to make a statement is Pierre-Emerick Aubameyang, who has so often been linked with a move to the Bernabeu. The Gabon international is at 11/10 to score in 90 minutes.
Apoel Nicosia vs Tottenham Hotspur
Spurs have been thoroughly impressive away from home, winning all three of their Premier League games
on the road. They adopted a different sort of strategy against Dortmund, inviting BVB onto them rather than continuously pressing. That was a more cautious approach, but they needn't adopt that here as Mauricio Pochettino's men shouldn't have many problems. It says it all that the hosts are at 10/1 to win.
Spartak Moscow vs Liverpool
Liverpool's notoriously shaky defence will be under scrutiny again after they let in another two goals against Leicester. They welcome back Sadio Mane as his suspension only applies to domestic games. Given both side's problems at the back, we're expecting an away win with over 2.5 goals at 5/4.
Monaco vs Porto
The Ligue 1 champions are back to winning ways after beating Lille 4-0 on Friday. Porto, meanwhile, have had a faultless start in the Primeira Liga but slipped to a 3-1 defeat in their first European game of the season against Besiktas. Monaco are slight favourites at 21/20.
Manchester City vs Shakhtar Donetsk
City are on fire. Pep Guardiola's side have scored 22 goals in their last five games in all competitions, so you have to feel for Shakhtar. Sergio Aguero needs just two goals to become the club's all-time leading goalscorer and you wouldn't bet against him doing that here. The Argentine is at 2/1 to score a brace.
Besiktas vs RB Leipzig
Leipzig are still feeling their way in the Champions League and this should make an interesting tie. Cenk Tosun is the danger man they need to watch out for, with the forward now reportedly attracting interest from several of Europe's top clubs. Timo Werner is in even better form, scoring nine in his last ten games, and he's at 4/1 as first goalscorer.
Napoli vs Feyenoord
It's hard to see anything other than a Napoli win taking place at the Stadio San Paolo. Feyenoord were easily put away by Manchester City last time out, and that was at home. Napoli have enjoyed a perfect start to Serie A, leading Juventus at the top on goal difference. They've scored 13 goals in three games, which is why they're clear favourites at 1/6 on.
Sevilla vs Maribor
Sevilla will be disappointed with anything less than a comfortable win against Maribor. Eduardo Berizzo's side have been in decent form and sit third in La Liga, though they've had a number of narrow wins against Las Palmas, Girona, and Getafe.
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